检索范围:
排序: 展示方式:
Interactions between remote ischemic conditioning and post-stroke sleep regulation
《医学前沿(英文)》 2021年 第15卷 第6期 页码 867-876 doi: 10.1007/s11684-021-0887-9
心肌远程调节及其临床相关性:现在一起来! Review
Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones
《工程(英文)》 2015年 第1卷 第4期 页码 490-499 doi: 10.15302/J-ENG-2015117
急性心肌梗死(AMI) 是世界上致死和致残的主要病因。及时再灌注法是AMI的标准疗法,能够缩小梗死面积,提高患者存活率和改善预后。然而,25 %的患者在患心肌梗死(Ml) 后会进一步发展成为心力衰竭(HF),且其中50%的患者会在5年内死亡。由于梗死面积是预断病人病情( 包括HF的形成) 的主要指标,因此,改善心肌的治疗方法具有极大的应用前景。 在过去30年中,研究者已发现多种能够刺激内源性心肌保护通道的刺激物,这些刺激物能在缺血预适应(IPC)和缺血后适应以及心肌缺血情况下启动保护机制。当在心肌缺血发生前、发生期间或发生后即刻使用刺激物,在远离心脏的血管床中发生的短暂、可逆性局部缺血就会即刻引发心肌保护机制——这种现象被分别称为远程缺血预适应,远程缺血期适应和远程缺血后适应。尽管目前的研究尚未完全阐明远程缺血预适应(RIPC) 的作用机制,但RIPC与IPC在机制上有很多共同之处。RIPC的发现使研究转向了远程非缺血刺激的应用,包括神经刺激( 脊髓刺激和迷走神经刺激) 以及电针(EA)。笔者与其他研究人员发现并阐述了非缺血现象的机制,并将其定义为远程创伤预适 应(RPCT)。通过刺激皮肤感觉神经来启动RPCT,这与穴位处神经刺激和EA既有相似性又有一定差异性。笔者在此次研究中还发现,可通过采用腹中线电刺激(与EA疗法相似) 来模拟RPCT,而且作为预适应刺激和后适应刺激( 在应用再灌注法时),这种激活心肌保护机制的模式是非常有效的。通过对这些心肌保护现象的研究,学术界对心肌保护机制形成了一种全面且综 合的理解,而且在过去的5~10 年期间, 这种理解变得逐渐清晰,即无论是缺血性刺激诱导还是非缺血性刺激诱导,其机制均相似。通过对文献中多种数据的综合考虑,我们认为所有的这些心肌保护“适应”现象均表示心肌保护机制的启动是从心肌适 应网(含有特定介质和心肌细胞生存感受器) 的不同切入点进行的,该切入点包括NF-κB、Stat3/5、蛋白激酶C、舒缓激肽和mitoKATP 通道。神经系统传导通路可能代表了一种激活心脏和其他器官适应的新机制。研究表明,由于IPC和RIPC存在一定风险并且无法应用于某些患者,所以它们很难被转化为临床应用。因此,近期又新兴了一种神经刺激和痛感刺激的应用,这是一种激活心肌适应的潜在的非缺血性无创方法。作为引起心脏保护作用众多方法之一的后适应重点强调了临床相关性,这种临床相关性有助于在现有成熟的药物与电子疗法中加速新的治疗方向的突破。
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 301-305 doi: 10.1007/s11684-013-0283-1
Systemic inflammatory response following myocardial ischemia-reperfusion injury (IRI) to a specific organ may cause injuries. Ischemic post-conditioning (IPostC) has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical settings. Enhancement of endogenous nitric oxide (NO) is one of the major mechanisms by which IPostC confers cardioprotection. However, the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism is unknown. Adiponectin (APN) is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory properties. Plasma levels of APN are decreased in obese subjects and in patients with type 2 diabetes. APN supplementation has been shown to increase NO production and attenuate myocardial IRI in normal (non-diabetic) animals. However, the effect of APN on myocardial injury in diabetic subjects, especially its potential in restoring the sensitivity of the diabetic heart to IPostC has not been investigated. In the current paper, we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IPostC and also highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in diabetes. This review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.
关键词: adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes
Genetics of ischemic and hemorrhagic stroke in Chinese population
Wei-Li ZHANG MD, PhD, Ru-Tai HUI MD, PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 21-28 doi: 10.1007/s11684-010-0013-x
关键词: genetics ischemic stroke hemorrhagic stroke association study
SHI Mingheng, DU Bin, ZHAO Yun
《能源前沿(英文)》 2007年 第1卷 第1期 页码 85-90 doi: 10.1007/s11708-007-0008-8
关键词: desiccant air-conditioning regeneration process air-conditioning system energy regeneration
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 20-29 doi: 10.1007/s11684-014-0371-x
Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
关键词: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
《医学前沿(英文)》 2022年 第16卷 第3期 页码 429-441 doi: 10.1007/s11684-021-0842-9
关键词: ischemic stroke microenvironment induced pluripotent stem cells (iPSCs) positron emission tomography (PET) quantitative proteomics
New developments in mobile air conditioning systems in China
Jiangping CHEN, Yu ZHAO, Zhaogang QI
《能源前沿(英文)》 2011年 第5卷 第1期 页码 53-58 doi: 10.1007/s11708-010-0137-3
关键词: global warming potential mobile air conditioning (MAC) energy saving new developments
Experimental investigation on desiccant air-conditioning system in India
Vijay MITTAL, B. Kant KHAN,
《能源前沿(英文)》 2010年 第4卷 第2期 页码 161-165 doi: 10.1007/s11708-009-0070-5
关键词: air ratios ambient conditions desiccant air-conditioning silica gel
Research progress in liquid desiccant air-conditioning devices and systems
Xiaohua LIU, Yi JIANG, Shuanqiang LIU, Xiaoyang CHEN,
《能源前沿(英文)》 2010年 第4卷 第1期 页码 55-65 doi: 10.1007/s11708-009-0082-1
关键词: liquid desiccant heat and mass transfer performance air-conditioning
Engine-driven hybrid air-conditioning system
Chaokui QIN , Hongmei LU , Xiong LIU , Gerhard SCHMITZ ,
《能源前沿(英文)》 2009年 第3卷 第1期 页码 109-116 doi: 10.1007/s11708-009-0003-3
关键词: engine-driven chiller desiccant wheel hybrid air-conditioning system energy consumption
YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai
《医学前沿(英文)》 2008年 第2卷 第4期 页码 352-355 doi: 10.1007/s11684-008-0067-1
Mark BOMBERG
《结构与土木工程前沿(英文)》 2010年 第4卷 第4期 页码 431-437 doi: 10.1007/s11709-010-0071-9
关键词: capillary active insulation integrated heating cooling and ventilation air conditioning (HVAC) and building enclosure dynamic insulation switchable thermal resistance variable U-value walls
Experimental investigation on oil-gas separator of air-conditioning systems
Dianbo XIN,Shuliang HUANG,Song YIN,Yuping DENG,Wenqiang ZHANG
《能源前沿(英文)》 2019年 第13卷 第2期 页码 411-416 doi: 10.1007/s11708-017-0447-9
关键词: variable refrigerant flow system oil-gas separator separation efficiency
Design and realization of a remote monitoring and diagnosis and prediction system for large rotating
Shaohong WANG, Tao CHEN, Jianghong SUN
《机械工程前沿(英文)》 2010年 第5卷 第2期 页码 165-170 doi: 10.1007/s11465-009-0090-1
关键词: large rotating machinery remote monitoring fault diagnosis prediction system
标题 作者 时间 类型 操作
Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemicpost-conditioning
null
期刊论文
Genetics of ischemic and hemorrhagic stroke in Chinese population
Wei-Li ZHANG MD, PhD, Ru-Tai HUI MD, PhD,
期刊论文
Investigation on regeneration and energy storage characteristics of a solar liquid desiccant air-conditioning
SHI Mingheng, DU Bin, ZHAO Yun
期刊论文
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
null
期刊论文
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic
期刊论文
New developments in mobile air conditioning systems in China
Jiangping CHEN, Yu ZHAO, Zhaogang QI
期刊论文
Experimental investigation on desiccant air-conditioning system in India
Vijay MITTAL, B. Kant KHAN,
期刊论文
Research progress in liquid desiccant air-conditioning devices and systems
Xiaohua LIU, Yi JIANG, Shuanqiang LIU, Xiaoyang CHEN,
期刊论文
Engine-driven hybrid air-conditioning system
Chaokui QIN , Hongmei LU , Xiong LIU , Gerhard SCHMITZ ,
期刊论文
Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset ischemic
YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai
期刊论文
concept of capillary active, dynamic insulation integrated with heating, cooling and ventilation, air conditioning
Mark BOMBERG
期刊论文
Experimental investigation on oil-gas separator of air-conditioning systems
Dianbo XIN,Shuliang HUANG,Song YIN,Yuping DENG,Wenqiang ZHANG
期刊论文